Selected Publications
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Niculescu AB, Hulvershorn L. Toward Early, Personalized, Rational Polypharmacy In Psychiatry: A Tri-Dimensional Approach. Psychopharm Review 2010. 45(2): 9-16
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Niculescu AB 3rd, Le-Niculescu H. Convergent Functional Genomics: What We Have Learned and Can Learn About Genes, Pathways, and Mechanisms. Neuropsychopharmacology. 2010. 35; 355–356
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SM Kurian, H Le-Niculescu, SD Patel, D Bertram, J Davis, C Dike, N Yehyawi, P Lysaker, J Dustin, M Caligiuri, J Lohr, DK Lahiri, JI Nurnberger Jr, SV Faraone, MA Geyer, MT Tsuang, NJ Schork, DR Salomon and AB Niculescu. Identification of blood biomarkers for psychosis using convergent functional genomics. Molecular Psychiatry. 2009 Epub Nov 24.
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McGrath CL, Glatt SJ, Sklar P, Le-Niculescu H, Kuczenski R, Doyle AE, Biederman J, Mick E, Faraone SV, Niculescu AB, Tsuang MT. Evidence for genetic association of RORB with bipolar disorder. BMC Psychiatry. 2009 Nov 12;9(1):70.
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Niculescu AB 3rd, Schork NJ, Salomon DR. Mindscape: A convergent perspective on life, mind, consciousness and happiness.Journal of Affective Disorders.. 2009 Jul 10.
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H. Le-Niculescu, S.D. Patel, M. Bhat, R. Kuczenski, S.V. Faraone, M.T. Tsuang, F.J. McMahon, N.J. Schork, J.I. Nurnberger Jr., and A.B. Niculescu III. Convergent Functional Genomics of Genome-Wide Association Data for Bipolar Disorder: Comprehensive Identification of Candidate Genes, Pathways and Mechanisms. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2009 Mar 5 150B(2):155-181
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H. Le-Niculescu, S. M. Kurian , N. Yehyawi, C. Dike, S.D. Patel, H.J. Edenberg, M. T. Tsuang, D. R. Salomon, J. I. Nurnberger Jr , A. B. Niculescu. Identifying Blood Biomarkers For Mood Disorders Using Convergent Functional Genomics. Molecular Psychiatry. 2008.
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Lixiang Liu, Tatiana Foroud, Xiaoling Xuei, Wade Berrettini, William Byerley, William Coryell, Rif El-Mallakh, Elliot Gershon, John Kelsoe, William Lawson, Dean MacKinnon, Melvin McInnis, Francis McMahon, Dennis Murphy, John Rice, William Scheftner, Alexander B. Niculescu, Eric. T. Meyer, Howard J. Edenberg, John I. Nurnberger Jr. Evidence of association between brain-derived neurotrophic factor (BDNF) gene and bipolar disorder. Psychiatric Genetics. 2008.
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Le-Niculescu H, McFarland MJ, Ogden CA, Balaraman Y, Patel S , Tan J, Rodd ZA, Paulus M, Geyer M, Edenberg HJ, Glatt SJ, Faraone SV, , Nurnberger JI, Kuczenski R, Tsuang MT and Niculescu AB. Phenomic, convergent functional genomic and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2008 Mar 5;147(2):134-166.
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Le-Niculescu H, McFarland MJ, Mamidipalli S, Ogden CA, Kuczenski R, Kurian SM, Salomon DR, Tsuang MT, Nurnberger Jr JI, Niculescu AB. Convergent Functional Genomics of bipolar disorder: from animal model pharmacogenomics to human genetics and biomarkers. Neurosci Biobehav Rev. 2007;31(6):897-903. Epub 2007 Jun 3. Review.
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Le-Niculescu H, Balaraman Y, Patel S, Tan J, Sidhu K, Jerome RE, Edenberg HJ, Kuczenski R, Geyer MA, Nurnberger JI Jr, Faraone SV, Tsuang MT, Niculescu AB Towards Understanding the Schizophrenia Code: An Expanded Convergent Functional Genomics Approach. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2007 Mar 5;144(2):129-58
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Alexander B.Niculescu III Polypharmacy in oligopopulations: what psychiatric genetics can teach biological psychiatry. Psychiatric Genetics 2006, 16:241-244
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Z.A.Rodd, B.A.Bertsch, W.N.Strother, H.Le-Niculescu, Y.Balaraman, E.Hayden, R.E.Jerome, L.Lumeng, Ji. Nurnberger Jr., H.J.Edenberg, W.J.McBride, and A.B.Niculescu Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach. The Pharmcogenomics Journal. 2007; 7: 222-56
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Alexander B. Niculescu, Len L. Lulow, Corey A. Ogden, Helen Le-Niculescu, Daniel R. Salomon, Nicholas J. Schork, Michael P. Caligiuri, James B. Lohr PhenoChipping of psychotic disorders: A novel approach for deconstructing and quantitating psychiatric phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 12; [Epub ahead of print]
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Michael P. Caligiuri, Gregory G. Brown, M.J. Meloy, Sonja Eberson, Alexander B. Niculescu, James B. Lohr Striatopallidal regulation of affect in bipolar disorder. J Affect Disorder. 2006 ;91 (2-3):235-42
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B. Bertsch, C.A. Ogden, K. Sidhu, H. Le-Niculescu, R. Kuczenski, A.B. Niculescu Convergent functional genomics: A Bayesian candidate gene identification approach for complex disorders. Methods 37. 2005; 274-279
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Niculescu AB. Genomic studies of mood disorders - the brain as a muscle? Minireview Genome Biology. 2005 March;6(4):215.1-215.4.
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Ogden CA, Rich ME, Schork NJ, Paulus MP, Geyer MA, Lohr JB, Kuczenski R, Niculescu AB. Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach. Molecular Psychiatry. 2004; 9:1007-1029
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Lohr JB, Kuczenski R, Niculescu AB. Oxidative Mechanisms and Tardive Dyskinesia. CNS Drugs 2003; 17:47-62
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Niculescu AB, Kelsoe JR. Finding Genes for Bipolar Disorder in the Functional Genomics Era: From Convergent Functional Genomics to Phenomics and Back. CNS Spectrums 2002; 7: 215-226
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Stahl SM, Niculescu AB. Molecular and Cellular Biology Research in Psychiatry. Chapter in Psychiatry as a Neuroscience, JJ Lopez-Ibor, W Gaebel, M Maj, N Sartorius (eds.), John Wiley & Sons, Ltd. 2002
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Niculescu AB, Akiskal HS. Sex hormones, Darwinism, and depression. Arch Gen Psychiatry. 2001 Nov;58(11):1083-4; discussion 1085-6
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Niculescu AB 3rd, Kelsoe JR. The human genome: genetic testing and animal models. Am J Psychiatry. 2001 Oct;158(10):1587
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Niculescu AB 3rd, Akiskal HS. Proposed endophenotypes of dysthymia: evolutionary, clinical and pharmacogenomic considerations. Mol Psychiatry. 2001 Jul;6(4):363-6. Review.
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Niculescu AB 3rd, Kelsoe JR. Convergent functional genomics: application to bipolar disorder. Ann Med. 2001 May;33(4):263-71. Review.
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Niculescu AB 3rd, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiol Genomics. 2000 Nov 9;4(1):83-91.
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Niculescu AB 3rd. The will to live, suicide, and euthanasia. Arch Intern Med. 2000 Jun 12;160(11):1706.
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Niculescu AB 3rd. Prophylactic antidepressant treatment before patients are admitted. Lancet. 2000 Jan 29;355(9201):406-7.
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Alexander B.Niculescu III, Xinbin Chen, Monique Smeets, Ludger Hengst, Carol Prives, Steven I.Reed Effects of p21 Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication. Molecular and Cellular Biology. Jan 1998, p. 629-643.