Pathways and Mechanisms
Anxiety Disorders
Le-Niculescu H, Balaraman Y, Patel SD, Ayalew M, Gupta J, Kuczenski R, Shekhar A, Schork N, Geyer MA,
Niculescu AB. Convergent Functional Genomics of Anxiety Disorders: Translational Identification of Genes,
Biomarkers, Pathways and Mechanisms. Translational Psychiatry. Epub 2011 May 24.
Top biological pathways for anxiety in different brain regions. Overlap between brain regions, and with the blood.
Bipolar Disorder
Patel SD, Le-Niculescu H, Koller DL, Green SD, Lahiri DK, McMahon F, Nurnberger JI, Niculescu AB. Coming to Grips With Complex Disorders: Genetic Risk Prediction in Bipolar Disorder Using Panels of Genes Identified Through Convergent Functional Genomics. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). Epub 2010 April 9.
Ingenuity Pathway Analysis of top candidate genes for Bipolar Disorder
Psychosis
SM Kurian, H Le-Niculescu, SD Patel, D Bertram, J Davis, C Dike, N Yehyawi, P Lysaker, J Dustin, M Caligiuri, J Lohr, DK Lahiri, JI Nurnberger Jr, SV Faraone, MA Geyer, MT Tsuang, NJ Schork, DR Salomon and AB Niculescu. Identification of blood biomarkers for psychosis using convergent functional genomics. Molecular Psychiatry. 2009 Epub Nov 24.
Ingenuity Pathway Analysis of top candidate biomarkers
Psychosis: disconnection and de-differentiation
Bipolar Disorder
H. Le-Niculescu, S.D. Patel, M. Bhat, R. Kuczenski, S.V. Faraone, M.T. Tsuang, F.J. McMahon, N.J. Schork, J.I. Nurnberger Jr., and A.B. Niculescu III. Convergent Functional Genomics of Genome-Wide Association Data for Bipolar Disorder: Comprehensive Identification of Candidate Genes, Pathways and Mechanisms. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics). 2009 Mar 5 150B(2):155-181
Ingenuity Pathway Analysis of top candidate genes
A comprehensive model for bipolar disorder pathophysiology.