Our Mission: Personalized Psychiatry.
We believe a worthwhile goal is to diagnose and treat patients in an individualized fashion, based on their profile of genes, biomarkers, and quantitative phenotypic (clinical) data, using low-dose rational polypharmacy to get synergistic benefits and minimize side-effects. Personalized diagnosis and treatment, for every patient, in every doctor’s office!
Our work points in a translational fashion to the issues of complexity, heterogeneity, overlap and interdependence of major psychiatric syndromes as currently defined by DSM. While some of this overlap might be due to limitations in precision of diagnostic ascertainments in humans and limitations in specificity to a disorder in animal model studies, an alternative and more compelling explanation is that the genetic and neurobiological structure of psychiatric disorders is modular in a Lego-like fashion, with building blocks in different permutations leading to different clinical disorders. There is a strong need for a move towards comprehensive empirical testing and away from categorical diagnostic classifications.
"The future is already here – it's just not evenly distributed" -William Gibson
“Knowledge is always a good thing- and more of it should be shared” –Sergey Brin, Google
“A diagnostic tool doesn’t have to be 100 percent accurate- just better than what we have now”- Todd Golub, Broad Institute of MIT and Harvard